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Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.
Sildenafil is available in 25mg, 50mg, and 100mg strengths.
Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.
Common side effects include:
Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.
Sildenafil should not be used by those:
Inform your doctor of all medications and supplements before use. Interactions may occur with:
Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.
Sildenafil is available by prescription only in the UK.
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AboutSildenafil is a proven, FDA-approved medication that belongs to the class of phosphodiesterase type 5 (PDE5) inhibitors. It is also sold under the brand name, which is also used to treat pulmonary arterial hypertension (PAH) and diabetes.
The use of sildenafil, the main ingredient in Viagra, is not only an effective remedy for erectile dysfunction but also a potential treatment for pulmonary hypertension (PH). The aim of this study was to investigate whether the use of sildenafil in combination with tadalafil and tamsulosin could increase the blood pressure and the efficacy of sildenafil treatment for PH. A retrospective study was conducted between December 2013 and December 2017 in the pulmonary hypertension management of patients using tadalafil, tamsulosin and sildenafil combination.
This was a retrospective study. Between December 2013 and December 2017, 740 patients were included in the study (with a mean age of 61 years, range from 35 to 89 years, with male gender 50%). The diagnosis of PH was made using the Pulmonary Hypertension (PH) Registry (Prelim).
The patients were randomly assigned to one of the three groups: group I, which received sildenafil, group II, which received tadalafil and tamsulosin combination, and group III, which received sildenafil, tadalafil and tamsulosin combination.
The results of the study were analyzed using Chi-square test and Wilcoxon rank sum test. The difference in the mean arterial blood pressure (MAP) between groups was estimated using the Mann-Whitney U test. P<0.05 was considered to be statistically significant.
The mean age of patients was 57.6 years (range 13–82 years), with a male gender of 50%. The mean number of symptoms was 10.6 ± 3.6, with a mean arterial pressure (MAP) of 9.1 ± 3.6 mmHg, a mean diastolic pressure (MAP) of 4.9 ± 4.1 mmHg and a mean pulmonary pressure (MAP) of 4.5 ± 3.6 mmHg. The mean diastolic pressure (MAP) was 6.1 ± 3.2 mmHg and 5.3 ± 3.6 mmHg in the group I, group II and group III, respectively. The mean pulmonary pressure (MAP) was 3.9 ± 3.8 mmHg in the group I, 5.3 ± 3.6 mmHg and 6.1 ± 3.2 mmHg in the group II, and 5.3 ± 3.6 mmHg in the group III, respectively. The mean age of the patients was 67.6 years (range 13–82 years), with a male gender of 50%. The mean number of symptoms was 13.9 ± 3.2, with a mean arterial pressure (MAP) of 9.7 ± 3.5 mmHg, a mean diastolic pressure (MAP) of 4.4 ± 3.7 mmHg and a mean pulmonary pressure (MAP) of 3.8 ± 3.5 mmHg.
The average age of patients in the groups I, II and III was significantly different (P<0.001), with a mean age of 55.6 (range 18–88) years. The mean age of patients in the groups I, II and III was significantly different (P<0.001). The mean age of patients in the groups I, II and III was significantly different (P<0.001) and the mean age of patients in the groups I, II and III was significantly different (P<0.001).
The use of sildenafil, tadalafil and tamsulosin combination was more effective in the treatment of PH than sildenafil, tadalafil and tamsulosin combination alone.
Citation:Olejos J, Gao R, Chen Y, Zhou R, Zhang H, Wu H, Zhou D, et al. (2021) ‘Combination therapy with tadalafil and tamsulosin for the treatment of pulmonary hypertension’.oon.DOI: 10.13021/jc.2707-2633.20.20.636.742.1921.2021.28.2021.2021.2021.2021.2021.2021.2021.2021.2021.2021.2021.2021.2021.2021.2021.2021.2021.2021.2021.2021.2021.2021.
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